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Question: Sterically stabilised (stealth) nanoparticles have been clinically approved for a wide range of applications. Explain how steric stabilisation improves nanoparticles in vivo performance.

10 Oct 2022,2:26 AM

 

(a)      A research and development department in a large multinational biopharmaceutical company is looking to develop an oral anti-cancer medicine. The initial hit compound has shown over 90% protein binding efficiency, high membrane permeability, and good solubility in the solvent DMSO. The solubility values of the hit compound in water, FaSSF and FeSSF are 1 mg/L, 0.1 mg/L and 10 mg/L.

Given the maximum dose of this anti-cancer medicine is 10 mg, what BCS class does this drug belong to? Please provide the numeric reason for your answer.

 

[50%]

 

(b)        Sterically stabilised (stealth) nanoparticles have been clinically approved for a wide range of applications. Explain how steric stabilisation improves nanoparticles in vivo performance.

Give an example of stealth nanoparticles.

[50%]

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